Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29869121 | 1.00 | MAP4K1 (0.63) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922401 | 1.00 | MAP4K1 (0.63) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29869035 | 1.00 | MAP4K1 (0.63) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922398 | 1.00 | MAP4K1 (0.63) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922493 | 0.94 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922592 | 0.94 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29869424 | 0.94 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29869138 | 0.94 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922482 | 0.91 | MAP4K1 (0.64) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922546 | 0.91 | MAP4K1 (0.64) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112239473-B | Process for preparing tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114127067-A | Tricyclic compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-112239473-A | Tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2021-01-19 | — | — | CN | disclosed |