Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28505749 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL28501865 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL29869859 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL22922557 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL29868818 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL29869046 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL22922558 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL22922477 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL22922478 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 | |
| SCHEMBL29869214 | 1.00 | MAP4K1 (1.00) | MAP4K1PIK3CGMAP3K11TNIKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112239473-B | Process for preparing tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114127067-A | Tricyclic compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-112239473-A | Tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2021-01-19 | — | — | CN | disclosed |