Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 9/20 | 0.73 |
| ▸ | TNIK | Q9UKE5 | 12/20 | 0.64 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.62 |
| ▸ | IKBKB | O14920 | 2/20 | 0.60 |
| ▸ | CHUK | O15111 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | SGK1 | O00141 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | CDK1 | P06493 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513743 | 0.87 | MAP4K1 (0.60) | MAP3K11TNIKMAP4K1 | |
| SCHEMBL28503233 | 0.85 | MAP3K11 (0.54) | MAP3K11TNIKMAP4K1IKBKBCHUK | |
| SCHEMBL722116 | 0.85 | MAP3K11 (1.00) | MAP3K11TNIKMAP4K1IKBKBCHUK | |
| SCHEMBL723895 | 0.85 | MAP3K11 (1.00) | MAP3K11TNIKMAP4K1IKBKBCHUK | |
| SCHEMBL28511325 | 0.84 | MAP4K1 (0.57) | MAP3K11TNIKMAP4K1 | |
| SCHEMBL28499626 | 0.84 | MAP4K1 (0.61) | MAP3K11TNIKMAP4K1 | |
| SCHEMBL28514908 | 0.84 | MAP4K1 (0.58) | MAP3K11TNIKMAP4K1ABL1INSR | |
| SCHEMBL28510070 | 0.84 | MAP3K11 (0.53) | MAP3K11TNIKMAP4K1IKBKBCHUK | |
| SCHEMBL28506325 | 0.83 | MAP4K1 (0.57) | MAP3K11TNIKMAP4K1ABL1INSR | |
| SCHEMBL15154839 | 0.82 | MAP3K11 (0.85) | MAP3K11TNIKMAP4K1IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |