Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28556404 | 1.00 | HTR2C (0.54) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL13354770 | 0.89 | CA1 (0.56) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL21590395 | 0.89 | CA1 (0.56) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL21594461 | 0.89 | CA1 (0.56) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL5506978 | 0.89 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL19696891 | 0.89 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL8715969 | 0.89 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| Hydrochloric Acid SCHEMBL30632601 | 0.88 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL29724285 | 0.88 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL30292457 | 0.87 | HTR2C (0.49) | HTR2CSMN1; SMN2NPC1RAB9APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843856-B | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-114867727-A | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-114787159-A | BRM targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-111989321-A | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2020-11-24 | — | — | CN | disclosed |