Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299638 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL2298539 | 0.85 | POLB (0.54) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL30785613 | 0.84 | MAPT (0.68) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL2299066 | 0.84 | MAPT (0.68) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL2852951 | 0.83 | MALT1 (0.45) | KDM4EALDH1A1MALT1 | |
| SCHEMBL2859858 | 0.81 | CCR1 (0.52) | SMN1; SMN2RAB9ANPC1HTTKDM4E | |
| SCHEMBL5681145 | 0.81 | MALT1 (0.51) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL2064195 | 0.81 | MAPT (0.76) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL30147712 | 0.81 | POLB (0.56) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL21605000 | 0.81 | POLB (0.56) | SMN1; SMN2MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |