Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.65 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31657077 | 0.90 | PTPN11 (0.52) | PTPN11KCNH2 | |
| SCHEMBL20388730 | 0.87 | PTPN11 (0.73) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31657083 | 0.87 | PTPN11 (0.72) | PTPN11KCNH2 | |
| SCHEMBL22941500 | 0.86 | PTPN11 (0.63) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23901702 | 0.86 | PTPN11 (0.53) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31657056 | 0.85 | PTPN11 (0.60) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31657067 | 0.85 | PTPN11 (0.60) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL22941866 | 0.85 | PTPN11 (0.62) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23901765 | 0.85 | PTPN11 (0.73) | PTPN11KCNH2 | |
| SCHEMBL24642957 | 0.85 | PTPN11 (0.73) | PTPN11KCNH2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223285-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2025-07-10 | — | — | US | disclosed |
| CN-117263942-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-112166110-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2021-01-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250223285-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN5, PTPN1, PTPRJ | PTPN11 13/4885KCNH2 4068/4885MAPK3 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.