Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 18/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850438 | 0.86 | TLR7 (0.47) | TLR7TLR8 | |
| SCHEMBL2850624 | 0.82 | TLR8 (0.41) | TLR7TLR8 | |
| SCHEMBL2849252 | 0.81 | TLR7 (0.55) | TLR7 | |
| SCHEMBL2849551 | 0.80 | TLR7 (0.46) | TLR7TLR8 | |
| SCHEMBL14472148 | 0.78 | TLR7 (0.82) | TLR7TLR8 | |
| SCHEMBL2849037 | 0.78 | TLR7 (0.52) | TLR7 | |
| SCHEMBL2875199 | 0.77 | TLR7 (0.84) | TLR7 | |
| SCHEMBL2843499 | 0.77 | TLR7 (0.56) | TLR7TLR8 | |
| SCHEMBL2854662 | 0.76 | TLR7 (0.52) | TLR7 | |
| SCHEMBL2847878 | 0.75 | TLR7 (0.48) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222648-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | AstraZeneca AB (SE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067081-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | WO | disclosed |