Known targets — ChEMBL curated mechanism
APH1AAPH1BNCSTNPSEN1PSEN2PSENEN
The experimentally established mechanism targets of Nirogacestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 known ✓ | P49768 | 20/20 | 0.99 |
| ▸ | PSEN2 known ✓ | P49810 | 20/20 | 0.99 |
| ▸ | APH1B known ✓ | Q8WW43 | 20/20 | 0.99 |
| ▸ | NCSTN known ✓ | Q92542 | 20/20 | 0.99 |
| ▸ | APH1A known ✓ | Q96BI3 | 20/20 | 0.99 |
| ▸ | PSENEN known ✓ | Q9NZ42 | 20/20 | 0.99 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nirogacestat SCHEMBL30074516 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL27231324 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL27231326 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL19183016 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL31142147 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL27214389 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL31142148 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL30074517 | 1.00 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL13184754 | 0.99 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL1796299 | 0.99 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323677-A | Retinal pigment epithelium and photoreceptor bilayer and uses thereof | 富士胶片细胞动力公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112204134-A | Method for differentiating ocular cells and use thereof | 富士胶片细胞动力公司 | 2021-01-08 | — | — | CN | disclosed |