Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342604 | 0.74 | NR1H2 (0.33) | NR1H2KDM1AESR2KMT2AUSP2 | |
| SCHEMBL4242555 | 0.74 | PLAT (0.35) | NR1H2KDM1AMAPK1GPR119 | |
| SCHEMBL29603337 | 0.72 | ESR2 (0.31) | NR1H2KDM1AESR2KMT2ACTSK | |
| SCHEMBL4439029 | 0.71 | NR1H2 (0.42) | NR1H2ADORA1ESR2USP2SMN1; SMN2 | |
| SCHEMBL9442950 | 0.71 | ESR2 (0.37) | NR1H2KDM1AESR2USP2SMN1; SMN2 | |
| SCHEMBL27233080 | 0.70 | NAMPT (0.33) | NR1H2ESR2MAPK1 | |
| SCHEMBL7309434 | 0.70 | NR1H2 (0.38) | NR1H2KDM1AADORA1ESR2KMT2A | |
| SCHEMBL31218507 | 0.69 | CHRM2 (0.44) | NR1H2KDM1AESR2CTSKUSP2 | |
| SCHEMBL14112126 | 0.68 | USP2 (0.40) | NR1H2KDM1AESR2KMT2ACTSK | |
| SCHEMBL7307321 | 0.68 | NR1H2 (0.41) | NR1H2KDM1AADORA1ESR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112300059-B | Preparation method of PF-06651600 intermediate | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-112300059-A | Preparation method of PF-06651600 intermediate | 广东东阳光药业有限公司 | 2021-02-02 | — | — | CN | disclosed |