Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.62 |
| ▸ | CDK2 | P24941 | 5/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CDC7 | O00311 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314069 | 0.77 | CDK2 (1.00) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL22684842 | 0.77 | CDK4 (0.76) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL4154285 | 0.75 | CDK2 (0.62) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL4169064 | 0.72 | CDK2 (0.68) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL18453159 | 0.72 | CDK4 (0.68) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL4163059 | 0.72 | CDK2 (0.68) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL4170529 | 0.72 | CDK2 (0.54) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL20550438 | 0.69 | CDK4 (0.61) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL1888363 | 0.68 | PIK3CA (0.46) | CDK4CDK2CCNE1ROCK1KDM4E | |
| SCHEMBL20550293 | 0.67 | CDK4 (0.54) | CDK4CDK2CCNE1ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010844-B | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | disclosed |