Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.53 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.47 |
| ▸ | SGK1 | O00141 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 5/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | IL2 | P60568 | 3/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502252 | 0.82 | MAP4K1 (0.65) | MAP4K1TNIKCAMKK2SGK1AXL | |
| Formamide SCHEMBL28513775 | 0.81 | MAP4K1 (0.55) | MAP4K1TNIKSGK1NTRK1IL2 | |
| SCHEMBL21592893 | 0.81 | MAP4K1 (0.57) | MAP4K1TNIKCAMKK2SGK1AXL | |
| SCHEMBL28504384 | 0.80 | MAP4K1 (0.66) | MAP4K1TNIKNTRK1IL2ABL1 | |
| Formamide SCHEMBL28508690 | 0.80 | MAP4K1 (0.53) | MAP4K1TNIKSGK1NTRK1IL2 | |
| SCHEMBL21592895 | 0.80 | MAP4K1 (0.57) | MAP4K1TNIKCAMKK2SGK1AXL | |
| SCHEMBL21592600 | 0.80 | MAP3K11 (0.66) | MAP4K1TNIKNTRK1IL2DYRK1A | |
| SCHEMBL21592956 | 0.79 | MAP4K1 (0.60) | MAP4K1TNIKNTRK1IL2ABL1 | |
| SCHEMBL21592842 | 0.79 | MAP4K1 (0.60) | MAP4K1TNIKNTRK1IL2ABL1 | |
| SCHEMBL21592874 | 0.79 | MAP4K1 (0.58) | MAP4K1TNIKCAMKK2SGK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |