Sugi Predict

Sugi Predict / Compounds / SCHEMBL28512183

SCHEMBL28512183

SCHEMBL28512183

Cc1cc(N)ccc1N(C)CCN(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.43
▸ PDE10A Q9Y233 1/20 0.39
▸ HRH3 Q9Y5N1 1/20 0.39
▸ CASP1 P29466 3/20 0.38
▸ PHLPP2 Q6ZVD8 1/20 0.37
▸ CYP3A4 P08684 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ MAPT P10636 5/20 0.35
▸ KDM4E B2RXH2 3/20 0.35
▸ LMNA P02545 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ THRB P10828 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ NOS1 P29475 1/20 0.33
▸ HTR7 P34969 1/20 0.33
▸ GAA P10253 2/20 0.33
▸ NR4A1 P22736 1/20 0.33
▸ PTK2B Q14289 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30221431 0.83 HRH3 (0.40) ALDH1A1HRH3CASP1PHLPP2CYP3A4
SCHEMBL11751589 0.83 HRH3 (0.40) ALDH1A1HRH3CASP1PHLPP2CYP3A4
SCHEMBL24900466 0.81 HRH3 (0.39) ALDH1A1HRH3PHLPP2CYP3A4MAPT
SCHEMBL30221663 0.81 HRH3 (0.39) ALDH1A1HRH3PHLPP2CYP3A4MAPT
SCHEMBL15872033 0.81 SMN1; SMN2 (0.46) ALDH1A1HRH3CYP3A4KDM4EMEN1
SCHEMBL31357831 0.80 HRH3 (0.38) ALDH1A1HRH3PHLPP2MAPTKDM4E
SCHEMBL6814753 0.80 CYP3A4 (0.42) ALDH1A1HRH3CASP1PHLPP2CYP3A4
SCHEMBL24900599 0.80 HRH3 (0.38) HRH3PHLPP2NOS1
SCHEMBL24992423 0.79 PRKCI (0.39) ALDH1A1HRH3PHLPP2TSHRMAPT
SCHEMBL24900438 0.77 HRH3 (0.36) HRH3PHLPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECH LIMITED (GB) 2026-05-21 — — US disclosed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 — — EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 — — WO disclosed
CN-112243439-A Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof 百济神州有限公司 2021-01-19 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER EGFR, KRAS, O60361 ALDH1A1 999/4885PDE10A 4462/4885HRH3 1940/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.