Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.67 |
| ▸ | ITK | Q08881 | 11/20 | 0.64 |
| ▸ | BTK | Q06187 | 5/20 | 0.62 |
| ▸ | TEC | P42680 | 3/20 | 0.61 |
| ▸ | BMX | P51813 | 3/20 | 0.61 |
| ▸ | TXK | P42681 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.61 |
| ▸ | LATS1 | O95835 | 1/20 | 0.61 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19256931 | 1.00 | EGFR (0.67) | EGFRITKBTKTECBMX | |
| SCHEMBL19257305 | 0.91 | EGFR (0.72) | EGFRITKBTKTECBMX | |
| SCHEMBL28528769 | 0.89 | ITK (0.65) | EGFRITKBTKKCNH2 | |
| SCHEMBL19256929 | 0.89 | ITK (0.65) | EGFRITKBTKKCNH2 | |
| SCHEMBL17475612 | 0.88 | BTK (0.79) | EGFRITKBTKTECBMX | |
| SCHEMBL17475613 | 0.88 | BTK (0.79) | EGFRITKBTKTECBMX | |
| SCHEMBL28528837 | 0.88 | ITK (0.63) | EGFRITKBTKKCNH2 | |
| SCHEMBL19256928 | 0.88 | ITK (0.63) | EGFRITKBTKKCNH2 | |
| SCHEMBL19257307 | 0.88 | ITK (0.64) | EGFRITKBTKJAK3KCNH2 | |
| SCHEMBL28519894 | 0.88 | ITK (0.64) | EGFRITKBTKJAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602834-B | Bruton's tyrosine kinase inhibitor | 北京盛诺基医药科技股份有限公司 | 2021-01-08 | — | — | CN | disclosed |