Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27443069 | 1.00 | TSHR (0.49) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL24255365 | 1.00 | TSHR (0.49) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL2575940 | 1.00 | TSHR (0.49) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL14728290 | 1.00 | TSHR (0.49) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL26813489 | 0.99 | TSHR (0.50) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL22515359 | 0.93 | TSHR (0.44) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL12801230 | 0.91 | KMT2A (0.50) | TSHRSMN1; SMN2HSD17B10TDP1HPGD | |
| SCHEMBL21070783 | 0.91 | POLB (0.48) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL21071168 | 0.91 | POLB (0.48) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 | |
| SCHEMBL21070555 | 0.91 | POLB (0.48) | TSHRSMN1; SMN2HSD17B10POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112105385-A | IRAK degrading agents and uses thereof | 凯麦拉医疗公司 | 2020-12-18 | — | — | CN | disclosed |