Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513447 | 1.00 | USP30 (0.70) | USP30PIK3CDHPGDSBTKGPR119 | |
| SCHEMBL28834119 | 0.85 | USP30 (0.64) | USP30BTKGPR119 | |
| SCHEMBL28834123 | 0.85 | USP30 (0.64) | USP30BTKGPR119 | |
| SCHEMBL29779081 | 0.85 | USP30 (0.81) | USP30PIK3CDHPGDSGPR119 | |
| SCHEMBL23292281 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK | |
| SCHEMBL529343 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK | |
| SCHEMBL596064 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK | |
| SCHEMBL22895552 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK | |
| SCHEMBL595857 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK | |
| SCHEMBL28911208 | 0.84 | USP30 (0.54) | USP30PIK3CDBTKGPR119SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707893-A | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-107484415-B | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2021-01-29 | — | — | CN | disclosed |