SCHEMBL28513486

SCHEMBL28513486

CCN(CC1CCC(c2ccnc3ccc(F)cc23)CC1)NC(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.46
CYP2C9 P11712 4/20 0.45
CYP2C8 P10632 3/20 0.45
TDO2 P48775 3/20 0.45
CHRNA1 P02708 1/20 0.45
CYP2C19 P33261 1/20 0.45
CYP3A4 P08684 1/20 0.45
KCNH2 Q12809 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20935286 0.83 IDO1 (0.51) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL28905180 0.82 IDO1 (0.49) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL21187176 0.80 IDO1 (0.60) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL23801461 0.77 IDO1 (0.54) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL19900045 0.77 IDO1 (0.54) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL22259470 0.76 IDO1 (0.50) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL22230784 0.76 IDO1 (0.50) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL22230783 0.75 IDO1 (0.51) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL21035079 0.75 IDO1 (0.56) IDO1CYP2C9CYP2C8TDO2CHRNA1
SCHEMBL22387491 0.75 IDO1 (0.56) IDO1CYP2C9CYP2C8TDO2CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110105275-B Amide derivatives, preparation method and medical application thereof 上海海雁医药科技有限公司 2020-12-29 CN disclosed