Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 6/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.49 |
| ▸ | CFTR | P13569 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18692286 | 0.92 | GRM1 (0.47) | GRM1GRM5CFTRPPARAPDK4 | |
| SCHEMBL28514357 | 0.86 | CFTR (0.48) | GRM1GRM5CFTRJAK1CDK9 | |
| SCHEMBL18704492 | 0.84 | GRM1 (0.49) | GRM1GRM5CFTRPPARAPDK4 | |
| SCHEMBL18720597 | 0.83 | CFTR (0.52) | CFTRPPARAF2RL1 | |
| SCHEMBL18717649 | 0.81 | CFTR (0.42) | GRM1GRM5CFTRPPARACDK9 | |
| SCHEMBL18693207 | 0.81 | PPARA (0.49) | CFTRPPARAF2RL1 | |
| SCHEMBL18694210 | 0.80 | JAK1 (0.43) | GRM1GRM5CFTRPDK4JAK1 | |
| SCHEMBL18694742 | 0.79 | CFTR (0.47) | GRM1GRM5CFTRPDK4JAK1 | |
| SCHEMBL18692155 | 0.78 | CFTR (0.54) | CFTRPPARAF2RL1 | |
| SCHEMBL18740523 | 0.76 | GRM5 (0.45) | GRM1GRM5CFTRPDK4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108513574-B | N-sulfonylated pyrazolo [3, 4-b ] pyridine-6-carboxamides and methods of use | 艾伯维公司 | 2021-01-05 | — | — | CN | disclosed |