Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21438414 | 1.00 | TTR (0.58) | TTRAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL21545149 | 1.00 | TTR (0.58) | TTRAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL29634023 | 0.83 | KDM4E (0.46) | TTRTPMTPTPN1CA1CA2 | |
| SCHEMBL21455367 | 0.83 | KDM4E (0.46) | TTRTPMTPTPN1CA1CA2 | |
| SCHEMBL28510333 | 0.83 | KDM4E (0.46) | TTRTPMTPTPN1CA1CA2 | |
| SCHEMBL1638962 | 0.82 | TTR (0.67) | TTRAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2439359 | 0.78 | CA1 (0.46) | TTRTPMTCA1CA2CA9 | |
| SCHEMBL2439356 | 0.78 | CA1 (0.46) | TTRTPMTCA1CA2CA9 | |
| SCHEMBL20870949 | 0.77 | AKR1C4 (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1SMN1; SMN2 | |
| SCHEMBL1114408 | 0.75 | TTR (1.00) | TTRAKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117164499-A | Substituted benzofurans, benzopyrroles, benzothiophenes and structurally related complement inhibitors | 拜奥克里斯特制药公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-112272553-B | Substituted benzofurans, benzopyrroles, benzothiophenes and structurally related complement inhibitors | 拜奥克里斯特制药公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-112272553-A | Substituted benzofurans, benzopyrrole, benzothiophenes and structurally related complement inhibitors | 拜奥克里斯特制药公司 | 2021-01-26 | — | — | CN | disclosed |