Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 8/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | UBLCP1 | Q8WVY7 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | HNF4A | P41235 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853076 | 0.85 | PTPN11 (0.53) | PTPN11PTPROSTAT3KAT8MCL1 | |
| SCHEMBL2848964 | 0.76 | PTPN11 (0.60) | PTPN11PTPROSTAT3KAT8MCL1 | |
| SCHEMBL13711654 | 0.75 | STAT3 (0.49) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1736062 | 0.74 | PTPN11 (0.55) | PTPN11PTPROSTAT3KAT8MCL1 | |
| SCHEMBL1734720 | 0.73 | PTPN11 (0.50) | PTPN11PTPROSTAT3 | |
| SCHEMBL1733825 | 0.73 | PTPN11 (0.58) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1815749 | 0.72 | PTPN11 (0.66) | PTPN11PTPROSTAT3MCL1 | |
| SCHEMBL1734576 | 0.72 | PTPN11 (0.62) | PTPN11PTPROSTAT3KAT8MCL1 | |
| SCHEMBL1734722 | 0.72 | PTPN11 (0.49) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL2853564 | 0.71 | PTPN11 (0.51) | PTPN11PTPROSTAT3KAT8FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | disclosed |