Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 4/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 15/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 12/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513291 | 0.88 | FGFR4 (0.67) | FGFR4FGFR3FGFR2FGFR1MEN1 | |
| SCHEMBL28512647 | 0.87 | FGFR4 (0.58) | FGFR4FGFR3FGFR2FGFR1MEN1 | |
| SCHEMBL28522513 | 0.87 | ABCG2 (0.47) | FGFR4FGFR3FGFR2FGFR1ABCG2 | |
| SCHEMBL16654477 | 0.85 | ABCG2 (0.46) | FGFR4FGFR3FGFR2FGFR1ABCG2 | |
| SCHEMBL24623013 | 0.84 | FGFR4 (0.52) | FGFR4FGFR3FGFR2FGFR1 | |
| SCHEMBL22348673 | 0.84 | FGFR4 (0.49) | FGFR4FGFR3FGFR2FGFR1 | |
| SCHEMBL30880141 | 0.84 | FGFR4 (0.49) | FGFR4FGFR3FGFR2FGFR1 | |
| SCHEMBL22348762 | 0.84 | FGFR4 (0.49) | FGFR4FGFR3FGFR2FGFR1 | |
| SCHEMBL30880149 | 0.84 | FGFR4 (0.49) | FGFR4FGFR3FGFR2FGFR1 | |
| SCHEMBL22348692 | 0.83 | FGFR3 (0.49) | FGFR4FGFR3FGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341431-A | Heterocyclic compounds as FGFR4 inhibitors | 齐鲁制药有限公司 | 2021-02-09 | — | — | CN | disclosed |