Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 1.00 |
| ▸ | MAPK13 | O15264 | 9/20 | 1.00 |
| ▸ | MAPK12 | P53778 | 9/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 9/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.74 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847240 | 0.89 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2844774 | 0.87 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3233958 | 0.87 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3231236 | 0.87 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2843750 | 0.85 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2846548 | 0.85 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2849082 | 0.84 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2844481 | 0.83 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2847071 | 0.83 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3233515 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853581-B1 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | MERCKLE GMBH (DE) | 2010-06-02 | — | — | EP | disclosed |
| EP-1853581-A1 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | MERCKLE GMBH (DE) | 2007-11-14 | — | — | EP | disclosed |
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| WO-2006089798-A1 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | MERCKLE GMBH (DE) | 2006-08-31 | — | — | WO | disclosed |
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-20040116416-A1 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2004-06-17 | — | — | US | disclosed |
| EP-1362045-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066458-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |