Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30405653 | 1.00 | MAPT (0.54) | MAPTHSP90AB1HSP90AA1OGAENPP2 | |
| SCHEMBL28561723 | 1.00 | MAPT (0.54) | MAPTHSP90AB1HSP90AA1OGAENPP2 | |
| SCHEMBL21528045 | 0.93 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1OGADDB1 | |
| SCHEMBL21528046 | 0.93 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1OGADDB1 | |
| SCHEMBL29669795 | 0.93 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1OGADDB1 | |
| SCHEMBL30805547 | 0.93 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1OGADDB1 | |
| SCHEMBL21528067 | 0.87 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1DDB1CRBN | |
| SCHEMBL21528108 | 0.87 | MAPT (0.64) | MAPTHSP90AB1HSP90AA1DDB1CRBN | |
| SCHEMBL25678377 | 0.85 | MAPT (0.44) | MAPTHSP90AB1HSP90AA1DDB1CRBN | |
| SCHEMBL25678394 | 0.85 | MAPT (0.44) | MAPTHSP90AB1HSP90AA1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112368289-B | C26-linked rapamycin analogues as MTOR inhibitors | 锐新医药公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-112368289-A | C26-linked rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2021-02-12 | — | — | CN | disclosed |