Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28521149 | 1.00 | MEN1 (0.49) | MEN1KMT2ATACR1ATMADRA2A | |
| SCHEMBL25289106 | 0.95 | ATM (0.45) | MEN1KMT2ATACR1ATMADRA2A | |
| SCHEMBL25247513 | 0.95 | ATM (0.45) | MEN1KMT2ATACR1ATMADRA2A | |
| SCHEMBL25238785 | 0.95 | ATM (0.45) | MEN1KMT2ATACR1ATMADRA2A | |
| SCHEMBL31198369 | 0.84 | TACR1 (0.46) | MEN1KMT2ATACR1ADRA2AADRA2B | |
| SCHEMBL16796794 | 0.84 | TACR1 (0.46) | MEN1KMT2ATACR1ADRA2AADRA2B | |
| SCHEMBL23323077 | 0.82 | MEN1 (0.65) | MEN1KMT2ATACR1HTR2CCHRNB4 | |
| SCHEMBL469013 | 0.82 | MEN1 (0.65) | MEN1KMT2ATACR1HTR2CCHRNB4 | |
| SCHEMBL29589447 | 0.82 | MEN1 (0.65) | MEN1KMT2ATACR1HTR2CCHRNB4 | |
| SCHEMBL25238033 | 0.80 | HTR2A (0.48) | MEN1KMT2AATMADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |