Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30147306 | 0.88 | MAPT (0.57) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL2296037 | 0.86 | POLB (0.74) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL2850399 | 0.86 | MAPT (0.74) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL595690 | 0.86 | MAPT (1.00) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL2871525 | 0.85 | MAPT (0.72) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL2856265 | 0.83 | MAPT (0.78) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL2858203 | 0.82 | MAPT (0.68) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL31252567 | 0.82 | MAPT (0.67) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL26125572 | 0.82 | MAPT (0.67) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 | |
| SCHEMBL15779140 | 0.81 | MAPK14 (0.57) | SMN1; SMN2POLBMAPTKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |