Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 19/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29230263 | 0.92 | DYRK2 (0.45) | DYRK2PIM1CDK6 | |
| SCHEMBL26680012 | 0.90 | DYRK2 (0.64) | DYRK2PIM1CDK6 | |
| SCHEMBL28521145 | 0.87 | DYRK2 (0.61) | DYRK2PIM1CDK6 | |
| SCHEMBL29230324 | 0.82 | DYRK2 (0.56) | DYRK2PIM1CDK6 | |
| SCHEMBL29230282 | 0.82 | DYRK2 (0.58) | DYRK2 | |
| SCHEMBL28515668 | 0.81 | DYRK2 (0.56) | DYRK2 | |
| SCHEMBL28591503 | 0.80 | CDK6 (0.63) | PIM1CDK6 | |
| SCHEMBL28604407 | 0.79 | CDK6 (0.60) | DYRK2PIM1CDK6 | |
| SCHEMBL28585099 | 0.78 | CDK6 (0.58) | DYRK2PIM1CDK6 | |
| SCHEMBL26447969 | 0.78 | DYRK2 (0.83) | DYRK2PIM1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146213-A | Benzothiazole pyrimidine amine DYRK2 inhibitor and preparation method and application thereof | 江苏天士力帝益药业有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-113149978-A | Intermediate compound, preparation method and application thereof | 中国药科大学 | 2021-07-23 | — | — | CN | disclosed |
| CN-112390793-B | CDK6/DYRK2 double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2021-04-27 | — | — | CN | disclosed |
| CN-112390793-A | CDK6/DYRK2 double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2021-02-23 | — | — | CN | disclosed |