Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.49 |
| ▸ | SRC | P12931 | 7/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 9/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.46 |
| ▸ | PRKCA | P17252 | 5/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26662097 | 0.90 | JAK2 (0.47) | CDC7CDK19JAK2PRKD3CDK2 | |
| SCHEMBL25346221 | 0.86 | JAK2 (0.49) | ABL1BCRCDC7CDK19PDGFRB | |
| SCHEMBL25346211 | 0.86 | JAK2 (0.49) | ABL1BCRCDC7CDK19PDGFRB | |
| SCHEMBL26850819 | 0.82 | JAK2 (0.53) | CDC7CDK19JAK2PRKD3CDK2 | |
| SCHEMBL24300848 | 0.78 | JAK2 (0.51) | ABL1CDC7CDK19JAK2CDK2 | |
| SCHEMBL26850833 | 0.78 | JAK2 (0.51) | ABL1CDC7CDK19JAK2CDK2 | |
| SCHEMBL23275729 | 0.77 | JAK2 (0.55) | EGFRJAK2JAK3 | |
| SCHEMBL29713627 | 0.77 | JAK2 (0.55) | EGFRJAK2JAK3 | |
| SCHEMBL29901242 | 0.77 | JAK2 (0.55) | EGFRJAK2JAK3 | |
| SCHEMBL29901156 | 0.77 | JAK2 (0.55) | EGFRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142675-B | Small molecule compound as JAK kinase inhibitor and application thereof | 嘉兴特科罗生物科技有限公司 | 2021-11-30 | — | — | CN | disclosed |
| CN-112142675-A | Small molecule compound as JAK kinase inhibitor and application thereof | 嘉兴特科罗生物科技有限公司 | 2020-12-29 | — | — | CN | disclosed |