Sugi Predict

Sugi Predict / Compounds / SCHEMBL28526212

SCHEMBL28526212

SCHEMBL28526212

CC1(O)CCC(F)(CNc2ccc(S(N)(=O)=O)cc2[N+](=O)[O-])CC1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 15/20 0.54
▸ PKM P14618 4/20 0.54
▸ POLB P06746 2/20 0.54
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ GAA P10253 8/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ LMNA P02545 2/20 0.46
▸ NPSR1 Q6W5P4 2/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ HTT P42858 2/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ CA12 O43570 1/20 0.44
▸ CA1 P00915 1/20 0.44
▸ CA2 P00918 1/20 0.44
▸ CA9 Q16790 1/20 0.44
▸ DOT1L Q8TEK3 1/20 0.43
▸ GFER P55789 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28525704 0.85 MAPT (0.51) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL29482090 0.85 MAPT (0.54) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL22581515 0.85 MAPT (0.54) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL29589101 0.84 MAPT (0.53) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL1699995 0.84 MAPT (0.53) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL29482091 0.84 MAPT (0.53) MAPTPKMPOLBSMN1; SMN2GAA
Hydrochloric Acid SCHEMBL29482106 0.83 MAPT (0.52) MAPTPKMPOLBSMN1; SMN2GAA
Hydrochloric Acid SCHEMBL22581377 0.83 MAPT (0.52) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL16039403 0.82 MAPT (0.53) MAPTPKMPOLBSMN1; SMN2GAA
SCHEMBL22653537 0.82 MAPT (0.48) MAPTPKMPOLBSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4545515-A1 BCL-2 INHIBITORS BeiGene Switzerland GmbH (CH) 2025-04-30 — — EP disclosed
US-20240376104-A1 Bcl-2 Inhibitors BEIGENE LTD. (KY) 2024-11-14 — — US disclosed
US-12077536-B2 BCL-2 inhibitors BEIGENE, LTD. (KY) 2024-09-03 — — US disclosed
CN-117683029-A Bcl-2 inhibitors 百济神州有限公司 2024-03-12 — — CN disclosed
CN-117430601-A Bcl-2 inhibitors 百济神州有限公司 2024-01-23 — — CN disclosed
CN-112437772-B Bcl-2 inhibitors 百济神州有限公司 2023-11-21 — — CN disclosed
US-20220402915-A1 BCL-2 INHIBITORS BEONE MEDICINES I GMBH (CH) 2022-12-22 — — US disclosed
US-11420968-B2 Bcl-2 inhibitors BEIGENE, LTD. (KY) 2022-08-23 — — US disclosed
CN-112437772-A Bcl-2 inhibitors 百济神州有限公司 2021-03-02 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220402915-A1 BCL-2 INHIBITORS BCL2, BCL2L1, BCL2L2 MAPT 2900/4885PKM 4250/4885POLB 1879/4885
US-11420968-B2 Bcl-2 inhibitors BCL2, BCL2L1, BCL2L2 MAPT 2900/4885PKM 4250/4885POLB 1879/4885
US-12077536-B2 BCL-2 inhibitors BCL2, BCL2L1, BCL2L2 MAPT 2900/4885PKM 4250/4885POLB 1879/4885
US-20240376104-A1 Bcl-2 Inhibitors BCL2, BCL2L1, BCL2L2 MAPT 2900/4885PKM 4250/4885POLB 1879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.