Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15708821 | 0.89 | EPHX1 (0.68) | MAPTTP53EPHX1EPHX2CYP3A4 | |
| SCHEMBL15709316 | 0.89 | EPHX1 (0.68) | MAPTTP53EPHX1EPHX2CYP3A4 | |
| SCHEMBL9686565 | 0.86 | EPHX1 (0.63) | MAPTTP53EPHX1EPHX2CYP3A4 | |
| SCHEMBL11867688 | 0.83 | MAPT (0.51) | MAPTTP53CYP3A4ALDH1A1LMNA | |
| SCHEMBL11867696 | 0.83 | MAPT (0.51) | MAPTTP53CYP3A4ALDH1A1LMNA | |
| SCHEMBL4786318 | 0.83 | KDM4E (0.74) | MAPTTP53EPHX1EPHX2CA2 | |
| SCHEMBL4786327 | 0.83 | KDM4E (0.74) | MAPTTP53EPHX1EPHX2CA2 | |
| SCHEMBL15899245 | 0.82 | IDO1 (0.52) | MAPTTP53ALDH1A1LMNAHTT | |
| SCHEMBL15899241 | 0.82 | IDO1 (0.52) | MAPTTP53ALDH1A1LMNAHTT | |
| SCHEMBL31704912 | 0.81 | MAPT (0.68) | MAPTTP53EPHX1EPHX2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112472699-A | Combination methods for improving the therapeutic benefit of bisantrene and derivatives | 种族肿瘤学公司 | 2021-03-12 | — | — | CN | disclosed |