Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28527216 | 1.00 | ATM (0.36) | ATMLMNAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL16335867 | 0.81 | ATM (0.38) | ATMSMN1; SMN2KMT2APOLBMAPK10 | |
| SCHEMBL21378960 | 0.81 | POLB (0.48) | ATMLMNAPOLB | |
| SCHEMBL16335866 | 0.81 | ATM (0.38) | ATMSMN1; SMN2KMT2APOLBMAPK10 | |
| SCHEMBL425737 | 0.80 | — | — | |
| SCHEMBL29222629 | 0.80 | HDAC8 (0.42) | LMNAMAPTKMT2APOLBHDAC8 | |
| SCHEMBL363166 | 0.80 | — | — | |
| SCHEMBL1142180 | 0.80 | HDAC8 (0.42) | LMNAMAPTKMT2APOLBHDAC8 | |
| SCHEMBL15656336 | 0.79 | GAA (0.41) | ATMMAPTSMN1; SMN2KMT2APOLB | |
| SCHEMBL29148774 | 0.79 | GAA (0.41) | ATMMAPTSMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112566915-A | Thiadiazole IRAK4 inhibitor | 吉利德科学公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112566697-A | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112533924-A | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2021-03-19 | — | — | CN | disclosed |