⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239181 | 0.77 | — | — | |
| SCHEMBL981922 | 0.64 | — | — | |
| SCHEMBL4723167 | 0.61 | — | — | |
| SCHEMBL4052976 | 0.61 | — | — | |
| SCHEMBL7831243 | 0.58 | — | — | |
| SCHEMBL60558 | 0.58 | — | — | |
| SCHEMBL8499978 | 0.58 | — | — | |
| SCHEMBL25008 | 0.58 | — | — | |
| SCHEMBL10306549 | 0.58 | — | — | |
| SCHEMBL30498455 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022730-B1 | CLASS OF BIS-INDOLE COMPOUNDS USEFUL AS MEDICINES, AND PROCESS FOR THEIR PREPARATION | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1983-04-06 | — | — | EP | claimed |
| US-4347249-A | Class of seco bis-indolic compounds which can be used as drugs and a process for the preparation thereof | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1982-08-31 | — | — | US | claimed |
| EP-0022730-A1 | Class of bis-indole compounds useful as medicines, and process for their preparation | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1981-01-21 | — | — | EP | claimed |
| US-20100240737-A1 | ENZYME-PRODRUG THERAPY FOR PROSTHETIC JOINT REPAIR | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2010-09-23 | — | — | US | disclosed |
| US-7674454-B2 | Enzyme-prodrug therapy for prosthetic joint repair | INNOVATA LIMITED (GB) | 2010-03-09 | — | — | US | disclosed |
| EP-1725267-B1 | ENZYME-PRODRUG THERAPY FOR PROSTHETIC JOINT REPAIR | INNOVATA LTD (GB) | 2010-02-24 | — | — | EP | disclosed |
| EP-1406910-B1 | PREPARATION METHODS OF DERIVATIVES OF BISPHOSPHONATES | UNIV PARIS 13 (FR) | 2010-01-13 | — | — | EP | disclosed |
| EP-1725267-A2 | ENZYME-PRODRUG THERAPY FOR PROSTHETIC JOINT REPAIR | Innovata PLC (GB) | 2006-11-29 | — | — | EP | disclosed |
| US-7005533-B2 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 (FR) | 2006-02-28 | — | — | US | disclosed |
| US-20050260160-A1 | Enzyme-prodrug therapy for prosthetic joint repair | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2005-11-24 | — | — | US | disclosed |
| WO-2005084713-A2 | ENZYME-PRODRUG THERAPY FOR PROSTHETIC JOINT REPAIR | INNOVATA PLC (GB) | 2005-09-15 | — | — | WO | disclosed |
| US-20040266735-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 | 2004-12-30 | — | — | US | disclosed |
| EP-1406910-A1 | NOVEL BISPHOSPHONATE DERIVATIVES, THEIR PREPARATION METHODS AND USES | Universite Paris 13 (FR) | 2004-04-14 | — | — | EP | disclosed |
| US-20030036537-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS, 13 (FR) | 2003-02-20 | — | — | US | disclosed |
| WO-2003008425-A1 | NOVEL BISPHOSPHONATE DERIVATIVES, THEIR PREPARATION METHODS AND USES | UNIVERSITE PARIS 13 (FR) | 2003-01-30 | — | — | WO | disclosed |
| US-4347249-A | Class of seco bis-indolic compounds which can be used as drugs and a process for the preparation thereof | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1982-08-31 | — | — | US | disclosed |
| US-4347249-A | Class of seco bis-indolic compounds which can be used as drugs and a process for the preparation thereof | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) | 1982-08-31 | — | — | US | disclosed |
| EP-0022730-A1 | Class of bis-indole compounds useful as medicines, and process for their preparation | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1981-01-21 | — | — | EP | disclosed |
| EP-0022730-A1 | Class of bis-indole compounds useful as medicines, and process for their preparation | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1981-01-21 | — | — | EP | disclosed |