Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852244 | 0.96 | MAPT (0.48) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2848538 | 0.93 | MAPT (0.45) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2850524 | 0.91 | MAPT (0.43) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2860975 | 0.90 | MAPT (0.49) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2848317 | 0.90 | MAPT (0.46) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2856976 | 0.89 | MAPT (0.52) | NR3C1MAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2859102 | 0.89 | MAPT (0.45) | MAPTNPSR1SMN1; SMN2ORAI1TRPC1 | |
| SCHEMBL2861576 | 0.89 | MAPT (0.45) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2858533 | 0.89 | ATM (0.47) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 | |
| SCHEMBL2857981 | 0.88 | MAPT (0.51) | NR3C1MAPTNPSR1SMN1; SMN2ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |