Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.67 |
| ▸ | JAK1 | P23458 | 15/20 | 0.67 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393747 | 0.88 | JAK2 (0.68) | JAK2JAK1TYK2AXLJAK3 | |
| SCHEMBL30986052 | 0.88 | JAK2 (0.68) | JAK2JAK1TYK2AXLJAK3 | |
| SCHEMBL2396399 | 0.87 | JAK2 (0.69) | JAK2JAK1 | |
| SCHEMBL31103238 | 0.86 | JAK2 (0.50) | JAK2JAK1TYK2AXLJAK3 | |
| SCHEMBL31103385 | 0.85 | JAK2 (0.49) | JAK2JAK1TYK2AXLJAK3 | |
| SCHEMBL2395967 | 0.82 | JAK2 (0.49) | JAK2JAK1 | |
| SCHEMBL19304379 | 0.82 | JAK2 (0.68) | JAK2JAK1TYK2AXLJAK3 | |
| SCHEMBL2398827 | 0.81 | JAK2 (0.55) | JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL2394938 | 0.81 | JAK2 (0.48) | JAK2JAK1 | |
| SCHEMBL19304405 | 0.81 | JAK2 (0.69) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112494652-A | JAK1 inhibitors for the treatment of myelodysplastic syndrome | 因赛特公司 | 2021-03-16 | — | — | CN | disclosed |