Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 17/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197996 | 0.94 | NPSR1 (0.60) | NPSR1TLR7TLR8 | |
| SCHEMBL2853038 | 0.84 | NPSR1 (0.47) | NPSR1TLR7 | |
| SCHEMBL2849074 | 0.84 | NPSR1 (0.58) | NPSR1TLR7TLR8 | |
| SCHEMBL2853207 | 0.81 | NPSR1 (0.55) | NPSR1TLR7TLR8 | |
| SCHEMBL2847405 | 0.81 | TLR7 (0.72) | TLR7 | |
| SCHEMBL2850612 | 0.80 | NPSR1 (0.47) | NPSR1TLR7 | |
| SCHEMBL4198238 | 0.78 | NPSR1 (0.52) | NPSR1TLR7 | |
| SCHEMBL853999 | 0.76 | NPSR1 (0.51) | NPSR1TLR7TLR8 | |
| SCHEMBL6120485 | 0.76 | NPSR1 (0.51) | NPSR1TLR7TLR8 | |
| SCHEMBL30036469 | 0.76 | NPSR1 (0.51) | NPSR1TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222648-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | ASTRAZENECA AB (SE) | 2013-01-09 | — | — | EP | disclosed |
| EP-2222648-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | AstraZeneca AB (SE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067081-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | WO | disclosed |