Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31241622 | 1.00 | PDGFRA (0.48) | PDGFRAPDGFRBFGFR2KDRSRC | |
| SCHEMBL19196875 | 0.84 | PDGFRA (0.56) | PDGFRAPDGFRBFGFR2KDRSRC | |
| SCHEMBL12663519 | 0.81 | PDGFRA (0.51) | PDGFRAPDGFRBFGFR2KDRSRC | |
| SCHEMBL31241626 | 0.81 | PDGFRA (0.56) | PDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL28535002 | 0.81 | PDGFRA (0.56) | PDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL14279893 | 0.76 | KDR (0.50) | PDGFRAPDGFRBFGFR2KDRSRC | |
| SCHEMBL557790 | 0.76 | PDGFRA (0.61) | PDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL12663452 | 0.75 | PDGFRA (0.48) | PDGFRAPDGFRBFGFR2KDRSRC | |
| SCHEMBL17486951 | 0.74 | FGFR2 (0.48) | PDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL17486952 | 0.74 | PDGFRA (0.47) | PDGFRAPDGFRBFGFR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390749-A | Synthesis method of cabozantinib and intermediate thereof | 鲁南制药集团股份有限公司 | 2021-02-23 | — | — | CN | disclosed |