SCHEMBL2853503

SCHEMBL2853503

O=C(O)c1cc2ccccc2c2cc(Br)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 1.00
KMT2A Q03164 7/20 1.00
RXFP1 Q9HBX9 4/20 1.00
SOS1 Q07889 1/20 0.50
GPR35 Q9HC97 2/20 0.47
POLB P06746 2/20 0.47
HTT P42858 1/20 0.47
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 3/20 0.46
HPGD P15428 3/20 0.46
HSD17B10 Q99714 2/20 0.46
NR4A1 P22736 1/20 0.46
NR4A2 P43354 1/20 0.46
NR4A3 Q92570 1/20 0.46
CYP1A2 P05177 1/20 0.46
GLA P06280 1/20 0.46
CYP2C19 P33261 1/20 0.46
NPC1 O15118 1/20 0.46
CYP2D6 P10635 1/20 0.45
PPARG P37231 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9476154 0.88 MEN1 (0.79) MEN1KMT2ARXFP1GPR35POLB
SCHEMBL22319279 0.85 MEN1 (0.74) MEN1KMT2ARXFP1SOS1POLB
SCHEMBL522958 0.84 MEN1 (0.71) MEN1KMT2ARXFP1SOS1GPR35
SCHEMBL28756416 0.83 RXFP1 (0.70) MEN1KMT2ARXFP1SOS1GPR35
SCHEMBL12877805 0.81 MEN1 (0.68) MEN1KMT2ARXFP1GPR35POLB
SCHEMBL1758231 0.80 MEN1 (0.66) MEN1KMT2ARXFP1ALDH1A1HPGD
SCHEMBL1228020 0.79 MEN1 (0.65) MEN1KMT2ARXFP1GPR35POLB
SCHEMBL10946505 0.79 MEN1 (0.65) MEN1KMT2ARXFP1SOS1HTT
SCHEMBL30344464 0.79 MEN1 (0.65) MEN1KMT2ARXFP1GPR35POLB
SCHEMBL4302560 0.78 RXFP1 (0.64) MEN1KMT2ARXFP1GPR35POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993123-B2 Materials for organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-03-31 US disclosed
US-8993123-B2 Materials for organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-03-31 US disclosed
US-8993123-B2 Materials for organic electroluminescent devices MERCK PATENT GMBH (DE) 2015-03-31 US disclosed
CN-101939279-B Novel materials for organic electroluminescent devices MERCK PATENT GMBH 2015-03-25 CN disclosed
CN-101939279-A Novel materials for organic electroluminescent devices MERCK PATENT GMBH 2011-01-05 CN disclosed
US-20100327270-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2010-12-30 US disclosed
US-20100327270-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2010-12-30 US disclosed
US-20100327270-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2010-12-30 US disclosed
EP-2240425-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES Merck Patent GmbH (DE) 2010-10-20 EP disclosed
WO-2009100925-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2009-08-20 WO disclosed
WO-2009100925-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2009-08-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100327270-A1 NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES L1CAM, ELAVL1, EPCAM MEN1 835/4885KMT2A 4115/4885RXFP1 3696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.