Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.41 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (D)-Serine SCHEMBL23111833 | 0.92 | SLC7A5 (0.54) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| Serine SCHEMBL23111878 | 0.92 | SLC7A5 (0.54) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| (D)-Serine SCHEMBL23111923 | 0.90 | SLC7A5 (0.52) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| Serine SCHEMBL23111919 | 0.90 | SLC7A5 (0.52) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| (D)-Serine SCHEMBL17423637 | 0.90 | TP53 (0.55) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| Leucine SCHEMBL15322295 | 0.88 | SLC7A5 (0.69) | SLC7A5TDP1SLC1A1SLC1A3SLC1A2 | |
| Serine SCHEMBL15323105 | 0.88 | SLC7A5 (0.42) | SLC7A5TDP1SLC1A1SLC1A3SLC1A2 | |
| (D)-Serine SCHEMBL2029988 | 0.87 | SLC7A5 (0.54) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| Serine SCHEMBL1270313 | 0.87 | SLC7A5 (0.54) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 | |
| Serine SCHEMBL7066091 | 0.87 | SLC7A5 (0.54) | SLC7A5SLC1A1SLC1A3SLC1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107805309-B | Dynamic polymer with non-covalent cross-linked structure and application thereof | 翁秋梅 | 2021-03-19 | — | — | CN | disclosed |