Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.58 |
| ▸ | AKT2 | P31751 | 6/20 | 0.58 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.58 |
| ▸ | PRKCA | P17252 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | PRKCB | P05771 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.58 |
| ▸ | PRKACB | P22694 | 2/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591842 | 1.00 | AKT1 (0.58) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL1539458 | 0.87 | AKT1 (0.47) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL28534564 | 0.86 | AKT1 (0.57) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL1641583 | 0.86 | AKT1 (0.57) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL1591685 | 0.84 | AKT1 (0.76) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL28526551 | 0.84 | AKT1 (0.76) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL1529491 | 0.84 | AKT1 (0.63) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL1529390 | 0.83 | AKT1 (0.74) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL13509109 | 0.83 | AKT1 (0.74) | AKT1AKT2AKT3ROCK1PRKCA | |
| SCHEMBL676006 | 0.83 | AKT1 (0.51) | AKT1AKT2AKT3ROCK1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113365610-A | Methods of making and delivering bisantrene formulations | 现代化制药公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-112472699-A | Combination methods for improving the therapeutic benefit of bisantrene and derivatives | 种族肿瘤学公司 | 2021-03-12 | — | — | CN | disclosed |