SCHEMBL28540233

SCHEMBL28540233

Nc1ccc(C(O)c2ccc(F)c(NC(=O)c3cc(C(F)(F)F)nn3-c3cccc(CNC(=O)O)c3)c2)cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 18/20 0.77
CARM1 Q86X55 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18605066 0.95 KLKB1 (0.82) KLKB1CARM1
SCHEMBL28535060 0.93 KLKB1 (0.73) KLKB1
SCHEMBL17064931 0.91 KLKB1 (0.70) KLKB1
SCHEMBL18605187 0.90 KLKB1 (0.68) KLKB1CARM1
SCHEMBL18605156 0.90 KLKB1 (0.82) KLKB1CARM1
SCHEMBL28545931 0.89 KLKB1 (0.69) KLKB1
SCHEMBL18604855 0.88 KLKB1 (0.66) KLKB1CARM1
SCHEMBL31744206 0.88 KLKB1 (0.66) KLKB1CARM1
SCHEMBL18604943 0.87 KLKB1 (1.00) KLKB1
SCHEMBL30279508 0.87 KLKB1 (1.00) KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113307772-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2024-06-28 CN disclosed
CN-113307772-A Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2021-08-27 CN disclosed
CN-106257976-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2021-02-02 CN disclosed