Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.62 |
| ▸ | PKM | P14618 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25307688 | 0.84 | MAPT (0.59) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1810940 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL30074954 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL16037369 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL29398480 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL29398771 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL16037933 | 0.83 | MAPT (0.66) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL16038420 | 0.83 | MAPT (0.65) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL16039933 | 0.83 | MAPT (0.65) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL16039190 | 0.83 | MAPT (0.65) | MAPTPKMKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |