Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | CSF1R | P07333 | 2/20 | 1.00 |
| ▸ | FLT1 | P17948 | 2/20 | 1.00 |
| ▸ | PDGFRA | P16234 | 1/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.66 |
| ▸ | AXL | P30530 | 1/20 | 0.66 |
| ▸ | ABL2 | P42684 | 1/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30237789 | 1.00 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL30237860 | 0.99 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL28529099 | 0.99 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL30237515 | 0.95 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL28532465 | 0.95 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL28538255 | 0.93 | FLT3 (0.86) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL28524712 | 0.91 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL30238279 | 0.91 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL28529091 | 0.91 | FLT3 (0.98) | FLT3PDGFRBKDRCSF1RFLT1 | |
| SCHEMBL30237624 | 0.91 | FLT3 (0.98) | FLT3PDGFRBKDRCSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321568-B | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2023-02-17 | — | — | CN | claimed |
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | claimed |
| CN-112321568-B | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2023-02-17 | — | — | CN | disclosed |
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | disclosed |