Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | BID | P55957 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28135204 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL28163513 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL27463695 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL1425613 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL28164157 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL23768448 | 0.98 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL28182684 | 0.96 | TDP1 (0.47) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL461554 | 0.96 | TDP1 (0.50) | TDP1L3MBTL1LIPGKCNH2BID | |
| SCHEMBL29031761 | 0.95 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID | |
| Hydrogen Sulfide SCHEMBL28566437 | 0.95 | TDP1 (0.49) | TDP1L3MBTL1LIPGKCNH2BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109248647-B | Modified hydrotalcite/iron oxyhydroxide composite material and preparation method thereof | 武汉科技大学 | 2021-04-16 | — | — | CN | claimed |
| CN-109248647-B | Modified hydrotalcite/iron oxyhydroxide composite material and preparation method thereof | 武汉科技大学 | 2021-04-16 | — | — | CN | disclosed |