Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138628 | 0.98 | TSHR (0.51) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL18559456 | 0.98 | TSHR (0.51) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL22374013 | 0.98 | TSHR (0.51) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL20746760 | 0.98 | TSHR (0.51) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL18559450 | 0.98 | TSHR (0.51) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL18672469 | 0.97 | TSHR (0.50) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL19225148 | 0.97 | TSHR (0.50) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL11379210 | 0.96 | TSHR (0.53) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL2959379 | 0.95 | TSHR (0.49) | TSHRKCNA5KCNH2CYP2D6KCNE1 | |
| SCHEMBL7773406 | 0.95 | TSHR (0.49) | TSHRKCNA5KCNH2CYP2D6KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109248647-B | Modified hydrotalcite/iron oxyhydroxide composite material and preparation method thereof | 武汉科技大学 | 2021-04-16 | — | — | CN | claimed |
| CN-109248647-B | Modified hydrotalcite/iron oxyhydroxide composite material and preparation method thereof | 武汉科技大学 | 2021-04-16 | — | — | CN | disclosed |