Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.86 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.73 |
| ▸ | PDE2A | O00408 | 1/20 | 0.73 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.73 |
| ▸ | PDE6D | O43924 | 1/20 | 0.73 |
| ▸ | PDE8A | O60658 | 1/20 | 0.73 |
| ▸ | PDE9A | O76083 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | PDE6A | P16499 | 1/20 | 0.73 |
| ▸ | PDE6G | P18545 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682533 | 0.93 | PDE5A (0.95) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Lodenafil Carbonate SCHEMBL5008159 | 0.92 | PDE5A (0.84) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL17390250 | 0.91 | PDE5A (0.83) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL5008158 | 0.90 | PDE5A (0.81) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL23937394 | 0.89 | PDE5A (0.91) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL17390175 | 0.88 | PDE5A (0.85) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL23937271 | 0.88 | PDE5A (0.81) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL23937345 | 0.88 | PDE5A (0.84) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL21705396 | 0.88 | PDE5A (0.84) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Lodenafil SCHEMBL1058 | 0.88 | PDE5A (1.00) | PDE5APDE3BPDE3AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112566670-A | Nitric oxide releasing phosphodiesterase type 5 inhibitors | 尼科斯股份有限公司 | 2021-03-26 | — | — | CN | disclosed |