SCHEMBL28554184

SCHEMBL28554184

Cc1cc(S(=O)(=O)N(OC(=O)C(F)(F)F)c2cscn2)ncc1OC1CCN([C@H](C)c2ccccc2)CC1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 20/20 0.61
SCN1A P35498 15/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19613964 0.85 SCN8A (0.64) SCN8ASCN1A
SCHEMBL19613981 0.85 SCN8A (0.64) SCN8ASCN1A
SCHEMBL19613353 0.85 SCN8A (0.62) SCN8ASCN1A
SCHEMBL19614269 0.84 SCN8A (0.61) SCN8ASCN1A
SCHEMBL28554165 0.84 SCN8A (0.63) SCN8ASCN1A
Formic Acid SCHEMBL28960911 0.83 SCN8A (0.61) SCN8ASCN1A
Trifluoroacetic Acid SCHEMBL21772971 0.80 SCN8A (0.88) SCN8ASCN1A
Trifluoroacetic Acid SCHEMBL21772970 0.80 SCN8A (0.88) SCN8ASCN1A
Trifluoroacetic Acid SCHEMBL30845723 0.80 SCN8A (0.88) SCN8ASCN1A
SCHEMBL19613402 0.80 SCN8A (0.63) SCN8ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638898-B Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2024-04-09 CN disclosed
CN-112638898-A Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors 泽农医药公司 2021-04-09 CN disclosed