SCHEMBL28555205

SCHEMBL28555205

COC(=O)c1ccc(N2c3ccccc3Sc3ccccc32)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.67
MAPT P10636 1/20 0.56
KDM4E B2RXH2 3/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
HPGD P15428 1/20 0.54
ALOX12 P18054 1/20 0.54
CYP2C19 P33261 1/20 0.54
KMT2A Q03164 1/20 0.54
BCHE P06276 6/20 0.54
NPSR1 Q6W5P4 1/20 0.53
ACHE P22303 3/20 0.50
LMNA P02545 2/20 0.49
GAA P10253 1/20 0.49
TSHR P16473 1/20 0.49
PKM P14618 1/20 0.48
NOX1 Q9Y5S8 1/20 0.46
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29617998 1.00 HDAC6 (0.67) HDAC6MAPTKDM4ESMN1; SMN2CYP1A2
SCHEMBL17851122 0.82 HDAC6 (0.71) HDAC6MAPTKMT2ABCHEACHE
SCHEMBL30874618 0.82 HDAC6 (0.71) HDAC6MAPTKMT2ABCHEACHE
SCHEMBL7210458 0.82 HDAC6 (0.71) HDAC6MAPTKMT2ABCHEACHE
SCHEMBL22146537 0.82 HDAC6 (0.71) HDAC6MAPTKMT2ABCHEACHE
SCHEMBL17356865 0.81 TDP1 (0.51) HDAC6MAPTKDM4ESMN1; SMN2CYP1A2
SCHEMBL28545381 0.81 HDAC6 (0.69) HDAC6MAPTKMT2ABCHEACHE
SCHEMBL28077830 0.80 HDAC6 (0.68) HDAC6MAPTSMN1; SMN2CYP3A4HPGD
SCHEMBL19268847 0.80 HDAC6 (0.68) HDAC6MAPTSMN1; SMN2HPGDKMT2A
SCHEMBL28536428 0.79 P2RX4 (0.54) MAPTKDM4ESMN1; SMN2HPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112625004-B Novel photo-activated organic small molecule matrix, preparation method and application thereof in MALDI mass spectrometry detection 苏州大学 2022-10-11 CN disclosed
WO-2022126819-A1 PHOTOACTIVATED NOVEL ORGANIC SMALL-MOLECULAR MATRIX, PREPARATION METHOD THEREFOR AND USE THEREOF IN MALDI MASS SPECTROMETRY DETECTION 苏州大学 2022-06-23 WO disclosed
CN-113026036-B Method for synthesizing sulfur ylide compounds by using continuous flow electrochemical oxidation 南京工业大学 2022-06-07 CN disclosed
CN-113026036-A Method for synthesizing sulfur ylide compounds by using continuous flow electrochemical oxidation 南京工业大学 2021-06-25 CN disclosed
CN-112625004-A Novel photo-activated organic small molecule matrix, preparation method and application thereof in MALDI mass spectrometry detection 苏州大学 2021-04-09 CN disclosed