Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.95 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28214484 | 1.00 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| Bromide SCHEMBL27330265 | 1.00 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL26788 | 0.98 | HSD17B10 (1.00) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL29859415 | 0.98 | HSD17B10 (1.00) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8044778 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL11125458 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL9579917 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL29289466 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8044782 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 | |
| Water SCHEMBL28115600 | 0.95 | HSD17B10 (0.95) | HSD17B10TSHRSMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108203384-B | Method for preparing o-nitrobenzyl bromide | 山东海利尔化工有限公司 | 2021-03-16 | — | — | CN | disclosed |