Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL38660495 | 0.87 | EPHX1 (0.44) | EPHX1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL29449809 | 0.87 | EPHX1 (0.44) | EPHX1TSHRALDH1A1 | |
| SCHEMBL10593520 | 0.85 | EPHX1 (0.46) | EPHX1CASP2PPARATSHRALDH1A1 | |
| SCHEMBL8500458 | 0.82 | EPHX1 (0.39) | EPHX1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8497312 | 0.82 | EPHX1 (0.39) | EPHX1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8499702 | 0.82 | EPHX1 (0.39) | EPHX1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL9213836 | 0.81 | EPHX1 (0.42) | EPHX1PPARATSHRALDH1A1 | |
| SCHEMBL9206460 | 0.81 | EPHX1 (0.42) | EPHX1PPARATSHRALDH1A1 | |
| SCHEMBL2863417 | 0.81 | EPHX1 (0.46) | EPHX1CASP2PPARATSHRALDH1A1 | |
| Phosphoric Acid SCHEMBL9649922 | 0.80 | GGPS1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227213-A | Catalytic composition and thiol-ene-based composition with extended pot life | PPG工业俄亥俄公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-108350119-B | Catalytic composition and thiol-ene based composition with extended pot life | PPG工业俄亥俄公司 | 2021-04-20 | — | — | CN | disclosed |