Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298403 | 0.86 | MAPT (0.70) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28798719 | 0.84 | MAPT (0.62) | MAPTPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6319475 | 0.84 | MAPT (0.53) | MAPTPOLBSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2300679 | 0.83 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL22209242 | 0.83 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2856265 | 0.83 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1064768 | 0.83 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL595690 | 0.83 | MAPT (1.00) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24303272 | 0.82 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2852811 | 0.82 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |