Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.74 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408508 | 1.00 | PDE5A (0.74) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL29408491 | 0.93 | PDE5A (0.64) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL28569844 | 0.93 | PDE5A (0.64) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL290397 | 0.93 | PDE5A (0.63) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL291561 | 0.89 | PDE5A (0.66) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL28572041 | 0.87 | PDE5A (0.80) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL29408498 | 0.87 | PDE5A (0.80) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL28565209 | 0.87 | PDE5A (0.55) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29408484 | 0.87 | PDE5A (0.55) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL291180 | 0.86 | PDE5A (0.54) | PDE5AALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114984229-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | 奥默罗斯公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-112168972-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | 奥默罗斯公司 | 2021-01-05 | — | — | CN | disclosed |