Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.75 |
| ▸ | HPGD | P15428 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.75 |
| ▸ | CLK2 | P49760 | 1/20 | 0.75 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gatifloxacin SCHEMBL28295842 | 0.87 | KDM4E (0.77) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL28580476 | 0.86 | KDM4E (0.62) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| (R)-Gatifloxacin SCHEMBL5670068 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL2224369 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL22592 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL22591 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| SCHEMBL14010230 | 0.86 | KDM4E (0.87) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL29356306 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL30910969 | 0.86 | KDM4E (1.00) | KDM4EHPGDALDH1A1KCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL3565686 | 0.85 | KDM4E (0.98) | KDM4EHPGDALDH1A1KCNH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112824391-A | Propylene ketone derivative of gatifloxacin and preparation method and application thereof | 河南大学 | 2021-05-21 | — | — | CN | disclosed |